A new era of human population genetics

Congenital heart disease: entering a new era of human genetics.

Congenital heart disease (CHD) remains a leading cause of morbidity and mortality in childhood and is the most common human birth defect, affecting nearly 1% of all live births worldwide. The morphogenetic events that are disrupted during cardiogenesis that lead to CHD are now partially understood, as are many of the molecular networks that guide normal heart development. Studies of rare Mendel...

Population genetics: A new apportionment of human diversity

A worldwide survey of polymorphic molecular markers shows that the human population is genetically homogeneous, in close agreement with evidence from quite different genes and traits.

Population Genetics in the Genomic Era

A new editor to mark another era in genetics.

A new editor to mark another era in genetics When Human Molecular Genetics was founded more than a decade ago, its pages were full of linkage analyses of single gene defects. Over the years, the time taken to identify the causative gene has gone from years to months and many reports contain not only mapping and gene identification, but also functional analysis as well. More recently, technical ...

A new era for Type 2 diabetes genetics

The field of complex disease genetics has witnessed rapid progress over the past few months. The advent of genome-wide association scans (GWAS) has mediated a change in gear and the Type 2 diabetes (T2D) research community has set an unprecedented record with five genome-wide association studies published since February 2007 [1–6], increasing the number of confirmed Type 2 diabetes susceptibili...